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Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint
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[Translated article] Infrapatellar fat pad resection effect on the osteoarthritis development: Experimental study in
B Bravo1, J M Argüello2, F Forriol1
1Departamento de Ciencias Básicas, Facultad de Medicina, Universidad CEU-San Pablo, Madrid, Spain.
Revista Espanola De Cirugia Ortopedica Y Traumatologia
|November 22, 2023
Summary
The infrapatellar fat pad influences osteoarthritis progression by altering inflammatory markers. Removing this fat impacts gene expression in synovial fluid, while its presence increases specific inflammatory markers, highlighting its role in joint health.
Area of Science:
- Orthopedics
- Rheumatology
- Molecular Biology
Background:
- Synovial joint fat plays a role in maintaining joint structure.
- Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and bone.
- The infrapatellar fat pad (IPFP) is a key component of the knee joint's adipose tissue.
Purpose of the Study:
- To analyze the evolution of joint degeneration in knees with and without an intact adipose pack.
- To investigate the role of the IPFP in the inflammatory processes associated with osteoarthritis.
Main Methods:
- A sheep model of osteoarthritis was created by sectioning the anterior cruciate ligament.
- The IPFP was either preserved or completely removed in different groups.
- Histological and molecular analyses were performed on various joint tissues and fluids, examining gene expression of RUNX2, PTHrP, cathepsin-K, and MCP1.
Main Results:
- No significant morphological differences were observed between the groups.
- Absence of the fat pad led to increased RUNX2 expression in the synovial membrane and PTHrP and Cathepsin K in synovial fluid.
- Presence of the fat pad resulted in increased RUNX2 expression in the meniscus and MCP1 in synovial fluid.
Conclusions:
- The infrapatellar fat pad is implicated in the inflammatory response of osteoarthritis.
- Resection of the Hoffa fat pad alters pro-inflammatory marker expression.
- An intact fat pad model showed an increase in the pro-inflammatory marker MCP1 in synovial fluid.
