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Recent progress in MoS2 nanostructures for biomedical applications: Experimental and computational approach.
Shivani Bharti1, S K Tripathi2, Kedar Singh1
1School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Analytical Biochemistry
|November 22, 2023
Summary
Molybdenum disulfide (MoS2) nanostructures offer a biocompatible alternative for biomedical applications, including biosensing and drug delivery. Combined experimental and computational studies enhance understanding for developing advanced nanocarriers.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Molybdenum disulfide (MoS2) is a 2D material with unique physicochemical properties.
- MoS2 nanostructures offer biocompatibility, low toxicity, and high stability, making them suitable for biomedical applications.
- These nanostructures are explored as alternatives to toxic heavy metals in various applications.
Purpose of the Study:
- To explore the potential of MoS2 nanostructures in biomedical and biotechnology fields.
- To review advancements in synthesis, surface functionalization, and biocompatibility of MoS2 for safe biomedical use.
- To understand the parameters governing MoS2 nanostructure development for biomedical applications.
Main Methods:
- Literature review of experimental studies on MoS2 nanostructures.
- Inclusion of computational studies to elucidate MoS2 properties and biomolecule interactions.
- Discussion of synthesis approaches, surface functionalization, and biocompatibility enhancement.
Main Results:
- MoS2 nanostructures show promise in biosensing, nanodrug delivery, electrochemical detection, bioimaging, and photothermal therapy.
- Improved synthesis and functionalization strategies are crucial for enhancing MoS2 performance and safety.
- Computational studies provide insights into the mechanisms of MoS2 interaction with biological systems.
Conclusions:
- MoS2 nanostructures hold significant potential for developing advanced biomedical applications.
- Further research combining experimental and computational approaches is needed to optimize MoS2 for smart drug delivery and nano-carriers.
- Understanding MoS2 properties and interactions is key to unlocking their full potential in nanomedicine.

