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Circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective

Chunjie Huang1, Pooya Esfani Sarafraz2, Parisa Enayati3

  • 1School of Medicine, Nantong University, Nantong, China.

Cancer Cell International
|November 23, 2023
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in renal cancer, influencing drug resistance, metastasis, and cell death. Their abnormal expression highlights their potential as diagnostic and therapeutic targets for kidney cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are a distinct class of noncoding RNAs with stable structures.
  • They participate in crucial cellular functions, including microRNA sponging and gene expression regulation.
  • Aberrant circRNA expression is linked to renal cancer development.

Purpose of the Study:

  • To elucidate the characteristics and functions of circRNAs in renal cancer.
  • To investigate the role of circRNAs in drug resistance, metabolism, metastasis, cell growth, and apoptosis in kidney cancer.
  • To discuss the potential of circRNAs as prognostic and diagnostic biomarkers for renal malignancies.

Main Methods:

  • Literature review and synthesis of current research on circRNAs in renal cancer.
  • Analysis of circRNA involvement in key cancer hallmarks.
  • Exploration of circRNA applications in clinical diagnostics and therapeutics.

Main Results:

  • CircRNAs exhibit diverse roles in renal cancer progression, affecting critical cellular processes.
  • Abnormal circRNA expression patterns are associated with various aspects of kidney cancer.
  • CircRNAs show promise as biomarkers for diagnosis and prognosis, and as therapeutic targets.

Conclusions:

  • CircRNAs are integral to renal cancer pathogenesis and progression.
  • Understanding circRNA functions offers new avenues for kidney cancer treatment and early detection.
  • Further research into circRNAs is crucial for advancing renal cancer management.
Keywords:
BiomarkerCircRNARenal cell carcinomaTargeted therapy

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