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Design and synthesis of imidazo[1,2-a]pyridine-chalcone conjugates as antikinetoplastid agents

Devesh S Agarwal1, Richard M Beteck1, Kayhan Ilbeigi2

  • 1Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa.

Chemical Biology & Drug Design
|November 23, 2023
PubMed

Keywords:
Trypanosoma brucei bruceiTrypanosoma brucei rhodesienseantikinetoplastidchalconedrug likeliness propertiesimidazo[1,2-a]pyridineneglected tropical diseases (NTDs)

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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