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Expert Commentary on Hepatic Artery Infusion Pump Chemotherapy for Colorectal Liver Metastases

Skye C Mayo1

  • 1Division of Surgical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon.

Diseases of the Colon and Rectum
|November 23, 2023
PubMed
Abstract

No abstract available in PubMed .

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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