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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

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Related Experiment Video

Updated: Jun 22, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Thyroid nodule core needle biopsy - current approach.

Emrah Karatay1, Mirkhalig Javadov2, Hatice Kaya3

  • 1Department of Radiology, Ministry of Health Tuzla State Hospital, Istanbul, Türkiye. emrahkaratay1984@gmail.com.

Endokrynologia Polska
|November 23, 2023
PubMed
Summary
This summary is machine-generated.

Core needle biopsy (CNB) offers improved diagnostic accuracy for thyroid nodules compared to fine needle aspiration biopsy (FNAB). CNB provides more detailed tissue samples, reducing non-diagnostic results and aiding surgical decisions.

Keywords:
FNABcore needle biopsythyroid noduleultrasound

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Area of Science:

  • Endocrinology
  • Pathology
  • Radiology

Background:

  • Fine needle aspiration biopsy (FNAB) is standard for thyroid nodule evaluation but struggles with follicular lesions.
  • Challenges include non-diagnostic results and atypia of unclear significance (AUS)/follicular lesion of uncertain significance (FLUS).

Purpose of the Study:

  • To evaluate the effectiveness of core needle biopsy (CNB) in diagnosing thyroid nodules.
  • To compare CNB's diagnostic accuracy with FNAB, particularly for challenging follicular lesions.

Main Methods:

  • Introduction of spring-activated single- or double-action needles for CNB.
  • Obtaining sizeable tissue samples for detailed histological analysis.

Main Results:

  • CNB yields more detailed histological information, including capsular support.
  • CNB demonstrates fewer non-diagnostic and ambiguous results (AUS/FLUS) compared to repeated FNAB.
  • CNB facilitates the identification of thyroid nodules requiring surgery with low morbidity.

Conclusions:

  • Core needle biopsy is a valuable tool for improving thyroid nodule diagnosis.
  • CNB overcomes FNAB limitations, offering better accuracy and reduced ambiguous results.
  • Guidelines for thyroid CNB pathology reporting have been established by Korean professional societies.