Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging cDC1 biology and function for enhanced immunotherapy.

The Journal of experimental medicine·2026
Same author

Biodegradable microparticles promote anti-inflammatory innate immune memory through a size- and mTOR-dependent process.

Journal of leukocyte biology·2026
Same author

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T-cell responses and anti-tumor immunity by targeting conventional type 1 dendritic cells.

Immunology and cell biology·2025
Same author

The source of dietary fat influences anti-tumour immunity in obese mice.

Nature metabolism·2025
Same author

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.

Science advances·2025
Same author

Immunostimulatory nanoparticles go viral.

Nature materials·2023

Related Experiment Video

Updated: Jun 17, 2026

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K

Rational design of polymer-based particulate vaccine adjuvants.

Jorge Huete-Carrasco1, Roisin I Lynch1,2, Ross W Ward1

  • 1Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

European Journal of Immunology
|November 23, 2023
PubMed
Summary

Vaccine adjuvants are crucial for enhancing immune responses. Understanding how their physical properties, like size and charge, influence immunity is key to designing more effective vaccines against diseases and cancer.

Keywords:
adjuvantscellular immunitydendritic cellsmechanism of actionphysicochemical propertiespolymeric particlesrational designvaccines

More Related Videos

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.2K
Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection

Published on: September 1, 2023

1.9K

Related Experiment Videos

Last Updated: Jun 17, 2026

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.2K
Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection

Published on: September 1, 2023

1.9K

Area of Science:

  • Immunology
  • Vaccinology
  • Materials Science

Background:

  • Vaccine adjuvants are essential for potent immune responses but their mechanisms are not fully understood.
  • Particulate adjuvants, particularly polymer-based ones, offer formulation advantages and influence immune induction.
  • Rational design of adjuvants is needed to elicit specific cellular immunity for challenging diseases.

Purpose of the Study:

  • To review recent advances in understanding how particulate adjuvants modulate immune responses.
  • To explore how adjuvant physicochemical properties impact immune induction.
  • To guide the rational design of improved vaccine adjuvants.

Main Methods:

  • Literature review focusing on particulate and polymer-based adjuvants.
  • Analysis of how adjuvant properties (size, charge) affect immune modulation.
  • Discussion of adjuvant impact on antigen delivery and immune cell targeting.

Main Results:

  • Adjuvant physicochemical properties significantly influence antigen release, biodistribution, and immune cell uptake.
  • Particulate adjuvants impact lymphatic drainage, dictating innate and adaptive immunity.
  • Understanding these mechanisms aids in designing adjuvants for robust cellular immunity (CD8+ T-cells, Th1 responses).

Conclusions:

  • Physicochemical properties of particulate adjuvants are critical for their immunomodulatory effects.
  • Rational design principles based on these properties can lead to more effective vaccine adjuvants.
  • Improved adjuvants are essential for developing vaccines against intracellular pathogens and cancer.