Related Experiment Video

Updated: Jul 10, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

168

Podocyte involvement in the pathogenesis of preterm-related long-term chronic kidney disease

Lulu Zhang1,2,3, Jun Zheng2,3,4, Fangrui Ding2,3,5

  • 1Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.

Histology and Histopathology
|November 23, 2023
PubMed

Insights

Preterm birth increases chronic kidney disease (CKD) risk. This review explores how prematurity impacts kidney development, focusing on podocyte function and long-term CKD in infants.

Area of Science:

  • Neonatology
  • Nephrology
  • Developmental Biology

Background:

  • Neonatal intensive care advancements improve preterm infant survival rates.
  • Preterm birth is a significant risk factor for developing chronic kidney disease (CKD).
  • CKD in preterm infants poses economic and quality-of-life challenges.

Purpose of the Study:

  • To review the influence of prematurity on chronic kidney disease (CKD) development.
  • To specifically focus on the role of podocytes in CKD associated with preterm birth.
  • To identify potential strategies for early prevention and management of CKD in preterm infants.

Main Methods:

  • Literature review of current epidemiological data and research on prematurity and kidney disease.
  • Analysis of the nephron number hypothesis in the context of preterm birth.
  • Focused examination of podocyte structure and function in relation to preterm birth and CKD.

Main Results:

  • Preterm birth is strongly linked to an increased risk of long-term chronic kidney disease (CKD).
  • While the nephron number hypothesis is established, the specific role of podocytes in prematurity-associated CKD requires further investigation.
  • Understanding podocyte behavior is crucial for elucidating CKD pathogenesis in preterm infants.

Conclusions:

  • Prematurity significantly impacts long-term renal health, increasing CKD susceptibility.
  • Podocytes represent a key area for understanding the mechanisms linking preterm birth to CKD.
  • Further research into podocyte function is essential for developing targeted interventions for preterm infants at risk of CKD.

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

9.8K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.7K

Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.6K
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.4K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
90
Formation of Dilute Urine01:20

Formation of Dilute Urine

The formation of dilute urine is a critical renal adaptation that maintains fluid balance, particularly during periods of high fluid intake. This process primarily involves the juxtamedullary nephrons. By adjusting the permeability of water and ions in response to physiological conditions, the kidneys can either conserve or excrete water, resulting in concentrated or dilute urine.
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
1.6K