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Related Experiment Video

Updated: Jul 10, 2025

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
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Hydration Methods for Cisplatin Containing Chemotherapy: A Systematic Review.

Charlotte Sikking1, Kelly L Niggebrugge-Mentink2, A S Elise van der Sman3

  • 1Department of Clinical Pharmacy, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

The Oncologist
|November 23, 2023
PubMed
Summary

Optimal cisplatin hydration involves short, low-volume fluid administration with mannitol and magnesium to prevent kidney damage (nephrotoxicity). Further research is needed to compare diuretics and determine optimal mannitol and magnesium doses.

Keywords:
cisplatindiureticselectrolytesfluid therapykidney/drug effectsmagnesium

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Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Cisplatin chemotherapy can cause kidney damage (nephrotoxicity).
  • Preventive hydration strategies are crucial but not standardized.
  • This study reviews evidence to optimize hydration protocols for preventing cisplatin-induced nephrotoxicity (CIN).

Approach:

  • Systematic literature search of Pubmed and Embase databases (2021-2023).
  • Two independent reviewers screened and categorized 27 included articles.
  • Analysis focused on hydration volume, duration, diuretics, and electrolyte supplementation.

Key Points:

  • Short hydration schemes with lower fluid volumes were associated with less CIN.
  • Mannitol supplementation showed a protective effect in 4/7 studies.
  • Magnesium supplementation reduced nephrotoxicity risk in 7/9 studies.

Conclusions:

  • Optimal hydration for cisplatin involves short duration and limited volume.
  • Inclusion of mannitol and magnesium is recommended.
  • Further head-to-head trials are necessary to compare diuretics and establish optimal mannitol/magnesium dosages.