Related Experiment Video
Updated: Jul 10, 2025
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics
Yifan Di1, Ruizhu Deng1, Zhu Liu1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, China.
Abstract:
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor growth, metastasis, death and other biological processes. ROS-based nanodynamic therapies (NDTs) are becoming attractive due to non-invasive, low side effects and tumor-specific advantages. NDTs have rapidly developed into numerous branches, such as photodynamic therapy, chemodynamic therapy, sonodynamic therapy and so on. However, the complexity of the tumor microenvironment and the limitations of existing sensitizers have greatly restricted the therapeutic effects of NDTs, which heavily rely on ROS levels. To address the limitations of NDTs, various strategies have been developed to increase ROS yield, which is an urgent aspect for the positive development of NDTs. In this review, the nanodynamic potentiation strategies in terms of unique properties and universalities of NDTs are comprehensively outlined. We mainly summarize the current dilemmas faced by each NDT and the respective solutions. Meanwhile, the NDTs universalities-based potentiation strategies and NDTs-based combined treatments are elaborated. Finally, we conclude with a discussion of the key issues and challenges faced in the development and clinical transformation of NDTs.
Insights
Reactive oxygen species (ROS)-based nanodynamic therapies (NDTs) show promise for cancer treatment. This review explores strategies to enhance ROS production, overcoming tumor microenvironment challenges for improved therapeutic efficacy.
Area of Science:
- Oncology
- Nanomedicine
- Biochemistry
Background:
- Reactive oxygen species (ROS) are critical regulators of tumor progression and biological processes.
- ROS-based nanodynamic therapies (NDTs) offer non-invasive, tumor-specific cancer treatment with low side effects.
- Existing NDTs face limitations due to the complex tumor microenvironment and sensitizer constraints, impacting ROS levels and therapeutic outcomes.
Purpose of the Study:
- To comprehensively review nanodynamic potentiation strategies for enhancing ROS levels in NDTs.
- To outline current challenges and solutions for various NDT modalities.
- To discuss universal potentiation strategies and combination treatments based on NDTs.
Main Methods:
- Literature review focusing on ROS-based nanodynamic therapies.
- Analysis of current dilemmas and solutions for photodynamic, chemodynamic, and sonodynamic therapies.
- Elaboration of NDT potentiation strategies and combination therapies.
Main Results:
- NDTs are a rapidly developing field with diverse branches like photodynamic, chemodynamic, and sonodynamic therapies.
- Strategies to increase ROS yield are crucial for overcoming NDT limitations.
- Universal potentiation strategies and combination treatments offer promising avenues for NDT advancement.
Conclusions:
- Addressing tumor microenvironment complexity and sensitizer limitations is key to improving NDT efficacy.
- Developing strategies to potentiate ROS production is an urgent need for NDT advancement.
- Further research and clinical translation are essential for the successful development of NDTs.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...