Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

458
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
458
Glaucoma: Overview01:25

Glaucoma: Overview

594
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
594

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same author

Effects of a Novel Dexamethasone Hydrogel Drug Delivery System on Cytokine and Mucin Expression in a Three-Dimensional In Vitro Conjunctival Inflammation Model.

Investigative ophthalmology & visual science·2026
Same author

The influence of baseline aortitis on aortic dilation risk in GCA: a multicentre imaging study.

Rheumatology (Oxford, England)·2025
Same author

A 3D <i>Fusarium</i> keratitis model reveals isolate-specific adhesion and invasion properties in the <i>Fusarium solani</i> species complex.

mSphere·2025
Same author

Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from <i>Candida albicans</i> and <i>Fusarium falciforme</i>.

Journal of fungi (Basel, Switzerland)·2025
Same author

Long-term outcomes of trabeculectomy versus canaloplasty in open-angle glaucoma - an 11-year follow-up of the TVC study cohort.

BMC ophthalmology·2025

Related Experiment Video

Updated: Jul 10, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K

[Continuous Optimisation of Experimental Models - an Example from Glaucoma Research].

Raoul Verma-Fuehring1, Mohamad Dakroub1, Malik Salman Haider1

  • 1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Würzburg, Deutschland.

Klinische Monatsblatter Fur Augenheilkunde
|November 23, 2023
PubMed
Summary
This summary is machine-generated.

Researchers improved an in vitro porcine eye perfusion model for glaucoma therapy testing. Modifications enhanced stability and prevented leakage, offering a more reliable alternative to animal models.

More Related Videos

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.5K
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.7K

Related Experiment Videos

Last Updated: Jul 10, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.5K
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.7K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Surgical Innovation

Context:

  • Glaucoma research requires effective in vitro models for testing new therapies.
  • Existing in vitro porcine eye models face challenges with media leakage and mechanical instability.
  • There is a need for improved, reproducible alternatives to animal models in glaucoma research.

Purpose:

  • To modify and enhance an established in vitro porcine eye perfusion model.
  • To address limitations of media leakage and setup disintegration in previous models.
  • To improve the stability, handling, and data reliability of the perfusion model.

Summary:

  • Modified an in vitro porcine anterior segment model using compression rings, screws, nuts, and 3D-printed polylactide (PLA) mounts.
  • Enhanced model stability, prevented fluid leakage, and ensured consistent pressure transducer readings.
  • The improved PLA mounts demonstrated durability under experimental conditions, tolerating heat and disinfection.

Impact:

  • Increased efficacy and reproducibility of the in vitro glaucoma model.
  • Provides a more reliable and resource-efficient alternative to animal testing for glaucoma therapies.
  • Facilitates better comparability between tested eyes and more stable experimental data.