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Updated: Jul 10, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Ferroptosis resistance in cancer: recent advances and future perspectives
Xing Zhang1, Xiang Li1, Ran Xia1
1Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100(#), District of Chaoyang, Beijing 100124, China.
Abstract:
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death and has been implicated in the occurrence and development of various diseases, including heart disease, nervous system diseases and cancer. Ferroptosis induction recently emerged as an attractive strategy for cancer therapy. Ferroptosis has become a potential target for intervention in these diseases or injuries in relevant preclinical models. This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer, highlights redox status and metabolism's role in it. Combination therapy for ferroptosis has great potential in cancer treatment, especially malignant tumors that are resistant to conventional therapies. This review will lead us to have a comprehensive understanding of the future exploration of ferroptosis and cancer therapy. A deeper understanding of the relationship between ferroptosis resistance and metabolism reprogramming may provide new strategies for tumor treatment and drug development based on ferroptosis.
Insights
Ferroptosis, a cell death form, is key in diseases like cancer. Understanding resistance mechanisms and metabolism is crucial for developing new ferroptosis-based cancer therapies, especially for drug-resistant tumors.
Area of Science:
- Biochemistry
- Oncology
- Cell Biology
Background:
- Ferroptosis is an iron-dependent regulated cell death pathway implicated in various diseases, including cancer.
- Ferroptosis induction is a promising therapeutic strategy for cancer treatment.
- Understanding ferroptosis resistance is critical for effective cancer therapy.
Purpose of the Study:
- To review recent advancements in understanding ferroptosis resistance mechanisms in cancer.
- To highlight the roles of redox status and metabolism in ferroptosis resistance.
- To explore the potential of ferroptosis-based combination therapies for cancer treatment.
Main Methods:
- Literature review of recent progress on ferroptosis mechanisms and resistance in cancer.
- Analysis of the interplay between redox status, metabolism, and ferroptosis.
- Synthesis of current knowledge on ferroptosis-inducing agents and combination strategies.
Main Results:
- Ferroptosis resistance in cancer is influenced by complex redox and metabolic reprogramming.
- Combination therapies targeting ferroptosis show significant potential, particularly for resistant cancers.
- Metabolic alterations play a pivotal role in modulating sensitivity to ferroptosis.
Conclusions:
- A comprehensive understanding of ferroptosis resistance mechanisms is essential for advancing cancer therapy.
- Targeting metabolic pathways offers novel strategies for overcoming ferroptosis resistance.
- Ferroptosis-based therapies, especially in combination, hold great promise for treating challenging malignancies.
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