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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Other Disorders of Digestive System01:30

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Prolonged Gastrointestinal Manifestations After Recovery From COVID-19.

B Joseph Elmunzer1, Olafur S Palsson2, Nauzer Forbes3

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|November 23, 2023
PubMed
Summary

COVID-19 survivors hospitalized with the virus frequently experience long-term gastrointestinal (GI) issues and disorders of gut-brain interaction (DGBI). Severity of initial GI symptoms and psychological trauma significantly predict persistent GI problems post-COVID-19.

Keywords:
COVID-19Disorder of Gut-Brain InteractionIrritable Bowel SyndromeLong COVID

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Psychiatry

Background:

  • COVID-19, primarily a respiratory illness, exhibits significant gastrointestinal (GI) tropism.
  • Acute enteric infections are known to cause long-term GI disorders.
  • Hospitalization with COVID-19 may predispose individuals to prolonged gut manifestations.

Purpose of the Study:

  • To investigate the long-term GI impact of hospitalization with COVID-19.
  • To assess persistent GI symptoms and the development of disorders of gut-brain interaction (DGBI) in COVID-19 survivors.
  • To identify factors associated with GI symptom severity and DGBI development post-COVID-19.

Main Methods:

  • A follow-up survey was conducted 12-18 months after hospitalization in 530 COVID-19 survivors.
  • Survey instruments included the Rome IV Diagnostic Questionnaire for DGBI, COVID-related symptom scales, and a trauma symptom questionnaire.
  • Regression analysis explored predictors of GI symptom severity at follow-up.

Main Results:

  • 60.3% of respondents met criteria for at least one Rome IV DGBI, a higher prevalence than in the general US population.
  • Among those with GI symptoms during hospitalization, 42.1% retained symptoms at follow-up.
  • Higher initial GI symptom severity and psychological trauma (PTSD) were strongly associated with persistent GI symptoms and DGBI prevalence.

Conclusions:

  • Hospitalization with COVID-19 is associated with a high prevalence of DGBIs and persistent GI symptoms 12-18 months later.
  • The severity of GI symptoms during acute COVID-19 illness and the degree of psychological trauma are significant predictors of long-term GI issues.
  • Findings highlight the need for comprehensive assessment and management of GI and psychological sequelae in COVID-19 survivors.