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Updated: Jul 10, 2025

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

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Published on: February 23, 2018

Variant-Specific IgA Protects Against Omicron Infection.

Yun Shan Goh¹, Siew-Wai Fong¹, Pei Xiang Hor¹

¹A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research, Singapore, Singapore.

The Journal of Infectious Diseases

|November 23, 2023

Summary

Immunoglobulin A (IgA) antibody response, not IgG, was higher in individuals protected from Omicron infection after mRNA booster vaccination. This suggests IgA may play a role in preventing breakthrough infections.

Keywords:

COVID-19 IgA Omicron S protein SARS-CoV-2 antibodies mRNA vaccine

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Published on: September 8, 2023

Area of Science:

Immunology
Virology
Vaccinology

Background:

Emerging SARS-CoV-2 variants and waning immunity increase breakthrough infections.
Understanding vaccine-mediated protection is critical.

Purpose of the Study:

To investigate the role of antibody responses in protection against Omicron infection post-mRNA vaccination and boosting.

Main Methods:

Prospective cohort study of mRNA vaccinated and boosted individuals during the Omicron wave in Singapore.
Analysis of variant-specific IgA and IgG antibody levels.

Main Results:

Higher specific IgA, but not IgG, antibody responses were observed in uninfected individuals compared to infected individuals 1 month post-booster.
This difference was specific to variant-targeted antibodies.

Conclusions:

Immunoglobulin A (IgA) may contribute to protection against Omicron SARS-CoV-2 infection.
Findings highlight IgA's potential role in vaccine-induced immunity against evolving viral variants.