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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
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[Hemodynamic Changes in Chronic Liver Disease]
Sangyong Jo1,2, Kyungil Park1,2
1Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|November 24, 2023
Summary
Chronic liver disease leads to harmful hemodynamic changes, including splanchnic vasodilation and hyperdynamic circulation. These changes worsen portal hypertension and complications like ascites, decreasing blood pressure in advanced stages.
Area of Science:
- Cardiovascular Physiology
- Hepatology
Context:
- Chronic liver disease (CLD) significantly alters systemic hemodynamics.
- Progression of CLD is associated with developing splanchnic vasodilation and hyperdynamic circulatory state.
Purpose:
- To elucidate the hemodynamic alterations in chronic liver disease.
- To correlate these changes with disease progression and complications.
Summary:
- Hemodynamic changes in CLD initiate with splanchnic vasodilation and hyperdynamic circulation.
- Worsening vasodilation and hyperdynamic state exacerbate portal hypertension.
- Advanced CLD stages are characterized by decreased effective plasma volume and arterial pressure.
Impact:
- Understanding these hemodynamic shifts is crucial for managing CLD complications.
- Provides insights into the pathophysiology of ascites and other sequelae.
- Highlights the terminal hemodynamic profile in end-stage liver disease.
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