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Updated: Jul 10, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
[Sarcopenia in Chronic Liver Disease]
Kwang Il Seo1,2,3
1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Abstract:
Sarcopenia is a crucial factor in assessing the nutritional status of chronic liver disease patients and predicting their prognosis and survival. The serum ammonia level is closely associated with sarcopenia regarding ammonia, a key regulator in the liver-muscle axis. In addition, various changes in energy metabolism and hormones are also involved in sarcopenia. The psoas muscle area can represent the overall skeletal muscle mass in liver disease patients. Therefore, measuring the psoas muscle area with computed tomography or magnetic resonance imaging is considered an objective and reliable method for assessing muscle mass. Providing sufficient calorie and protein intake is crucial for preventing and treating sarcopenia. In addition, engaging in appropriate exercise and addressing concurrent hormonal and metabolic changes can be helpful.
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