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Updated: Jul 10, 2025

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Published on: February 16, 2018
Synthesis of Asymmetric Urea Derivatives from COS and Amines: Substrate Selection, Scope Studies, and Mechanism
Siliu Cheng1,2,3, Jiakai Wu1,2,3, Huijie Jia1,2,3
1College of Chemical Engineering, Inner Mongolia University of Technology, Aimin street 49, Xincheng District, Hohhot 010051, China.
Abstract:
A series of asymmetric ureas were synthesized by a one-pot reaction of amines and carbonyl sulfide (COS) under catalyst-free conditions. The highly selective synthesis of asymmetric urea was successfully achieved by the use of weakly nucleophilic aromatic amines and highly nucleophilic secondary aliphatic amines. Moreover, a reaction mechanism was proposed based on the detailed NMR and FTIR study. This efficient synthetic methodology provides a mild and selective method for synthesizing asymmetric urea derivatives.
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