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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Inflammation01:38

Inflammation

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Overview
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Introduction to the Integumentary System01:25

Introduction to the Integumentary System

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
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Related Experiment Video

Updated: Jul 10, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

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The Skin and Inflamm-Aging.

Rashi Agrawal1, Anne Hu1, Wendy B Bollag1,2,3

  • 1Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Biology
|November 24, 2023
PubMed
Summary
This summary is machine-generated.

Aging skin undergoes changes that impair its barrier function, potentially driving systemic inflammation. Understanding these age-related skin changes is key to developing therapies for aging skin and other tissues.

Keywords:
agingatopic dermatitisepidermal barrierepidermisinflammationkeratinocytespsoriasisskinxerosis

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Area of Science:

  • Dermatology
  • Gerontology
  • Immunology

Background:

  • The skin's unique position necessitates vital protective and metabolic functions.
  • Aging leads to significant changes in skin structure and function.
  • Impaired skin barrier function with age is linked to inflammation.

Purpose of the Study:

  • To explore the role of age-related skin changes in inflammation.
  • To investigate the concept of "inflamm-aging" originating from the skin.
  • To highlight the potential for skin-targeted therapeutics.

Main Methods:

  • Review of existing literature on skin aging and inflammation.
  • Analysis of the skin's contribution to systemic inflammatory mediators.
  • Exploration of the mechanisms linking skin barrier dysfunction to inflammation.

Main Results:

  • Aging impairs skin barrier function, increasing susceptibility to damage.
  • Skin inflammation in aging may contribute to sustained, sub-clinical systemic inflammation.
  • This "inflamm-aging" process may underlie various age-related declines.

Conclusions:

  • Age-related skin changes, particularly barrier dysfunction, are significant.
  • The skin is a potential major contributor to "inflamm-aging".
  • Further research into skin aging mechanisms could yield broad therapeutic benefits.