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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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The Skin and Inflamm-Aging.

Rashi Agrawal1, Anne Hu1, Wendy B Bollag1,2,3

  • 1Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Biology
|November 24, 2023
PubMed
Summary
This summary is machine-generated.

Aging skin undergoes changes that impair its barrier function, potentially driving systemic inflammation. Understanding these age-related skin changes is key to developing therapies for aging skin and other tissues.

Keywords:
agingatopic dermatitisepidermal barrierepidermisinflammationkeratinocytespsoriasisskinxerosis

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Area of Science:

  • Dermatology
  • Gerontology
  • Immunology

Background:

  • The skin's unique position necessitates vital protective and metabolic functions.
  • Aging leads to significant changes in skin structure and function.
  • Impaired skin barrier function with age is linked to inflammation.

Purpose of the Study:

  • To explore the role of age-related skin changes in inflammation.
  • To investigate the concept of "inflamm-aging" originating from the skin.
  • To highlight the potential for skin-targeted therapeutics.

Main Methods:

  • Review of existing literature on skin aging and inflammation.
  • Analysis of the skin's contribution to systemic inflammatory mediators.
  • Exploration of the mechanisms linking skin barrier dysfunction to inflammation.

Main Results:

  • Aging impairs skin barrier function, increasing susceptibility to damage.
  • Skin inflammation in aging may contribute to sustained, sub-clinical systemic inflammation.
  • This "inflamm-aging" process may underlie various age-related declines.

Conclusions:

  • Age-related skin changes, particularly barrier dysfunction, are significant.
  • The skin is a potential major contributor to "inflamm-aging".
  • Further research into skin aging mechanisms could yield broad therapeutic benefits.