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Surface Functionalised Optical Fibre for Detection of Hydrogen Sulphide.
Shaghayegh Baghapour1, Jasmine Nehema2, Wen Qi Zhang1,3
1Laser Physics and Photonic Devices Laboratory, UniSA STEM, University of South Australia, Adelaide, SA 5095, Australia.
Biosensors
|November 24, 2023
Summary
Researchers developed a novel optical fiber sensor for detecting hydrogen sulfide (HS⁻). This new system offers rapid and sensitive detection, crucial for monitoring diseases like cancer.
Area of Science:
- Analytical Chemistry
- Biomedical Engineering
- Materials Science
Background:
- Hydrogen sulfide (HS⁻) dysregulation is linked to diseases like cancer, necessitating accurate detection methods.
- 1,8-naphthalimide fluorescent probes offer potential for HS⁻ sensing.
Purpose of the Study:
- To develop and evaluate an optical fibre-based sensor for sensitive and rapid detection of hydrogen sulfide.
- To functionalize a fluorescent probe for covalent attachment to an optical fibre tip.
Main Methods:
- Synthesized two 1,8-naphthalimide fluorescent probes with an azide moiety.
- Modified one probe with (3-aminopropyl)triethoxysilane (APTES) for optical fibre coating.
- Analyzed probe performance using UV-Vis, fluorescence spectrophotometry, and an optical fibre setup, including XPS for coating confirmation.
Main Results:
- Both probes showed significant fluorescence enhancement (>2x) upon HS⁻ addition.
- The optical fibre sensor exhibited a rapid response time (2 min) compared to the solution probe (30 min).
- The sensor demonstrated pH insensitivity between pH 6.4 and 7.4.
Conclusions:
- The synthesized APTES-azide fluorophore enables the development of a fast and sensitive optical fibre-based HS⁻ sensing system.
- This technology holds promise for health monitoring and disease detection applications.
