Fabrication of an Azithromycin Sensor.

Area of Science:

• Materials Science
• Electrochemistry
• Analytical Chemistry

Background:

• Azithromycin (AZY) is a critical antibiotic with potential adverse effects on human health and the environment.
• Accurate monitoring of AZY concentrations is essential due to its widespread use and potential toxicity.
• Electrochemical sensors offer high sensitivity, selectivity, and cost-effectiveness for detecting various analytes.

Purpose of the Study:

• To fabricate a sensitive and selective electrochemical sensor for azithromycin (AZY) detection.
• To utilize a novel molybdenum disulfide/titanium aluminum carbide (MoS₂@Ti₃AlC₂) composite as an electrode modifier.
• To evaluate the sensing performance of the developed MoS₂@Ti₃AlC₂ modified glassy carbon electrode (GC) for AZY.

Main Methods:

• Synthesis of the MoS₂@Ti₃AlC₂ composite using a sonication method.
• Characterization of the composite using Powder X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray Spectroscopy (EDAX).
• Modification of a glassy carbon (GC) electrode with the synthesized composite and electrochemical sensing using linear sweep voltammetry.

Main Results:

• The MoS₂@Ti₃AlC₂ composite was successfully synthesized and characterized.
• The modified GC electrode exhibited excellent sensing performance for AZY detection.
• The sensor achieved a low detection limit of 0.009 µM and a sensitivity of 6.77 µA/µM.cm².

Conclusions:

• The MoS₂@Ti₃AlC₂ composite is a promising electrode material for developing efficient electrochemical sensors.
• The fabricated sensor demonstrates high sensitivity and a low detection limit for azithromycin monitoring.
• This work provides a valuable tool for the accurate and reliable detection of azithromycin in various applications.