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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

496
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
496

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Related Experiment Video

Updated: Jul 10, 2025

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
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Alzheimer's Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor.

Phan Gia Le1, Seong Hye Choi2, Sungbo Cho1,3

  • 1Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea.

Biosensors
|November 24, 2023
PubMed
Summary

Field-effect transistor (FET) biosensors offer sensitive detection of Alzheimer's disease (AD) biomarkers for early diagnosis. This review details FET mechanisms and their application in AD diagnostics, highlighting future prospects.

Keywords:
Alzheimer’s diseaseamyloid betabiomarkerselectrochemical sensorfield-effect transistor (FET)tau

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Sensor Technology

Background:

  • Alzheimer's disease (AD) is a neurodegenerative disorder causing dementia, primarily affecting individuals over 65.
  • Early detection of AD biomarkers is critical for timely diagnosis and effective treatment.
  • Current diagnostic methods require improvement for sensitivity and early-stage detection.

Purpose of the Study:

  • To provide a comprehensive overview of Field-Effect Transistor (FET) biosensors for Alzheimer's disease biomarker detection.
  • To discuss the operational mechanisms and features of FET-based sensors.
  • To analyze the applicability and future trends of FET biosensors in AD diagnostics.

Main Methods:

  • Review of existing literature on FET biosensor technology.
  • Detailed description of FET operational principles and characteristics.
  • Analysis of studies utilizing FET biosensors for Alzheimer's disease biomarker identification.

Main Results:

  • FET biosensors demonstrate high sensitivity in detecting various AD biomarkers at ultra-low concentrations.
  • FET technology shows significant potential for early and accurate diagnosis of Alzheimer's disease.
  • The review outlines the current state and advancements in FET-based AD detection.

Conclusions:

  • FET biosensors are a promising technology for the sensitive and early detection of Alzheimer's disease biomarkers.
  • Further development of FET devices could revolutionize AD diagnostics and patient management.
  • The review highlights the future prospects and trends for FET applications in neurodegenerative disease diagnosis.