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Updated: Jul 10, 2025

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
Topological Data Analysis for Multivariate Time Series Data
Anass B El-Yaagoubi1, Moo K Chung2, Hernando Ombao1
1Statistics Program, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
Abstract:
Over the last two decades, topological data analysis (TDA) has emerged as a very powerful data analytic approach that can deal with various data modalities of varying complexities. One of the most commonly used tools in TDA is persistent homology (PH), which can extract topological properties from data at various scales. The aim of this article is to introduce TDA concepts to a statistical audience and provide an approach to analyzing multivariate time series data. The application's focus will be on multivariate brain signals and brain connectivity networks. Finally, this paper concludes with an overview of some open problems and potential application of TDA to modeling directionality in a brain network, as well as the casting of TDA in the context of mixed effect models to capture variations in the topological properties of data collected from multiple subjects.
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