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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

594
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma.

Gabriella De Salvo1, Mohamed Oshallah1, Anastasios E Sepetis1

  • 1Ophthalmology Department, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.

Diagnostics (Basel, Switzerland)
|November 24, 2023
PubMed
Summary

Inner retinal thinning, particularly in the inner nuclear layer (INL) and hemisphere asymmetry (HA), may indicate branch retinal artery occlusion (BRAO). This finding aids in diagnosing past BRAO events and preventing future vascular incidents.

Keywords:
glaucoma module premium editionhemispheric asymmetryinner nuclear layerinner plexiform layerretinal artery occlusion

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Vascular Occlusion

Background:

  • Branch retinal artery occlusion (BRAO) and primary open-angle glaucoma (POAG) are distinct conditions affecting the retina.
  • Assessing tomographic retinal layer thickness is crucial for diagnosing and monitoring retinal diseases.

Purpose of the Study:

  • To evaluate and compare the tomographic retinal layer thickness in eyes with BRAO versus primary open-angle glaucoma (POAG).
  • To identify specific retinal layer changes indicative of BRAO.

Main Methods:

  • Retrospective review of 27 patients (16 with BRAO, 11 with POAG) who underwent SD-OCT scans.
  • Analysis included macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), neuroretinal rim (NRR), circumpapillary RNFL, and hemisphere asymmetry (HA).

Main Results:

  • Statistically significant differences in total IPL and INL thinning between BRAO and POAG groups (p=0.0067 and p<0.0001, respectively).
  • Significant hemisphere asymmetry (HA) differences for total macular thinning, mRNFL, GCL, IPL, and INL (p<0.0001).
  • No significant difference in average total retinal thinning, total mRNFL, and GCL thinning between groups.

Conclusions:

  • Unilateral inner retinal thinning, especially INL thinning and HA difference >17µm, may signify temporal BRAO.
  • These findings can aid in diagnosing previous, undiagnosed BRAO.
  • Early diagnosis may help prevent further retinal arterial occlusion and cerebrovascular events.