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Updated: Jul 10, 2025

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MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
Published on: February 17, 2012
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Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate
Johanna Marines1,2, Francesca Lorenzini1, Karima Kissa3
1AZELEAD, 377 rue du Pr Blayac, 34080 Montpellier, France.
Current Issues in Molecular Biology
|November 24, 2023
Abstract:
Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.

