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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Injectable hydrogels for localized drug delivery offer tunable release and non-swelling properties.
  • Current ethoxylated trimethylolpropane tri-3-mercaptopropionate (ETTMP) and poly(ethylene glycol) diacrylate (PEGDA) hydrogel synthesis faces challenges including poor solubility, slow gelation, and reproducibility issues.

Purpose of the Study:

  • To develop a reliable and reproducible synthesis procedure for ETTMP-PEGDA hydrogels.
  • To overcome limitations of existing synthesis methods, including slow gelation and poor ETTMP solubility.

Main Methods:

  • Investigated the impact of residual mercaptopropionic acid and alumina purification column height on gelation time.
  • Premixed ETTMP and PEGDA to enhance ETTMP solubility in water.
  • Conducted a sensitivity analysis of key variables in the synthesis process.

Main Results:

  • Achieved hydrogel synthesis with polymer concentrations from 15 to 90 wt%.
  • Reduced gelation times to under 2 minutes.
  • Obtained tunable hydrogel moduli ranging from 3.5 to 190 kPa.
  • Demonstrated ETTMP-PEGDA mixture stability at -20 °C for up to 2 months.

Conclusions:

  • The developed synthesis procedure provides a reliable method for producing ETTMP-PEGDA hydrogels.
  • These improved hydrogels are suitable for injectable, localized drug delivery with controllable drug release.
  • The enhanced storage stability facilitates easier handling, storage, and shipment of the hydrogel precursor mixture.