Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute appendicitis and Bacteroides fragilis.

R Pieper, L Kager, A A Lindberg

    Scandinavian Journal of Infectious Diseases. Supplementum
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Polyosides (encapsulated bacteria).

    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2000
    Same author

    Phase I clinical trials of aroA aroD and aroA aroD htrA attenuated S. typhi vaccines; effect of formulation on safety and immunogenicity.

    Vaccine·2000
    Same author

    Vaccination against enteric pathogens: from science to vaccine trials.

    Current opinion in microbiology·1999
    Same author

    Shigella flexneri type-specific antigen V: cloning, sequencing and characterization of the glucosyl transferase gene of temperate bacteriophage SfV.

    Gene·1997
    Same author

    Molecular characterization of the genes involved in O-antigen modification, attachment, integration and excision in Shigella flexneri bacteriophage SfV.

    Gene·1997
    Same author

    Construction and characterization of a live attenuated vaccine candidate against Shigella dysenteriae type 1.

    Infection and immunity·1997

    The Bacteroides fragilis group is common in normal and diseased appendices. High antibody responses to B. fragilis indicate ruptured appendix, not necessarily appendicitis itself.

    Area of Science:

    • Microbiology
    • Immunology

    Background:

    • The appendix harbors diverse bacterial communities, including anaerobic and aerobic species.
    • The role of specific bacteria, particularly the Bacteroides fragilis group, in appendicitis pathogenesis remains unclear.

    Purpose of the Study:

    • To investigate the prevalence of the Bacteroides fragilis group in normal and inflamed appendices.
    • To assess the humoral immune response to Bacteroides species in patients with appendicitis.

    Main Methods:

    • Bacterial cultures from 30 excised appendices (normal, inflamed, perforated).
    • Serological analysis of antibody titers against four Bacteroides species in paired patient sera.

    Main Results:

    • Bacteroides fragilis group bacteria were prevalent in all appendix types.

    Related Experiment Videos

  • Elevated antibody titers against B. fragilis were observed in patients with ruptured appendices.
  • No significant difference in antibody response to B. fragilis was found between inflamed and normal appendices.

    • Conclusions:

    • The Bacteroides fragilis group is a common commensal in the appendix.
    • Isolation of B. fragilis alone does not confirm its etiological role in appendicitis.
    • Significant antibody increases against B. fragilis are associated with appendix rupture.