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Updated: Jun 13, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Multiple Myeloma in 2023 Ways: From Trials to Real Life

Manlio Fazio1, Vittorio Del Fabro2, Nunziatina Laura Parrinello2

  • 1Post-Graduation School of Haematology, University of Catania, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.

Current Oncology (Toronto, Ont.)
|November 24, 2023
PubMed

Insights

Multiple myeloma treatments are advancing with new drugs from clinical trials and real-world data. Promising therapies like CAR-T cells offer hope for advanced multiple myeloma patients.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma is a relapsing hematologic malignancy.
  • Advances in molecular understanding have driven new drug development.
  • New therapies require integration of clinical trial and real-world data.

Purpose of the Study:

  • To review current multiple myeloma treatment regimens.
  • To compare clinical trial data with real-world patient experiences.
  • To highlight emerging therapies for advanced disease.

Main Methods:

  • Literature review of clinical trials.
  • Analysis of real-world data on multiple myeloma treatment.
  • Evaluation of novel therapeutic strategies.

Main Results:

  • New drugs are approved and integrated into treatment.
  • Discrepancies between clinical trials and real-world outcomes exist.
  • T-cell engagers and CAR-T cells show efficacy in advanced stages.

Conclusions:

  • Integrating clinical trial and real-world data is crucial for optimizing multiple myeloma therapy.
  • Novel immunotherapies like CAR-T cells represent a significant advancement.
  • Continued research is needed to refine treatment strategies for relapsing multiple myeloma.
Keywords:
CAR-T cells therapyautologous stem cell transplantationbispecific antigensdaratumumabfrailtyminimal residual diseasemultiple myelomareal-liferelapsed-refractory diseasesequencingstandard of care

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