MgO Nanoparticles Obtained from an Innovative and Sustainable Route and Their Applications in Cancer Therapy

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Materials Science

Background:

• Magnesium oxide nanoparticles (MgO NPs) synthesis methods can be optimized for efficiency and scalability.
• Understanding the biological impact of nanomaterials is crucial for their safe application.

Purpose of the Study:

• To evaluate the cytotoxic effects of MgO NPs on diseased cells.
• To assess the safety of MgO NPs on healthy cells.
• To explore the potential of MgO NPs in therapeutic applications.

Main Methods:

• Synthesized MgO NPs using a novel, scalable, and energy-efficient method.
• Characterized MgO NPs for size, morphology, and organization.
• Exposed melanoma and human skin fibroblast cells to various MgO NP concentrations for 72 hours.
• Assessed cellular viability and proliferation using viable count assays.

Main Results:

• Synthesized MgO NPs exhibited a controlled morphology with sizes under 10 nm.
• MgO NPs demonstrated significant cytotoxic activity against melanoma cells in a concentration-dependent manner.
• No adverse effects on the vitality or proliferation of healthy human skin fibroblasts were observed.

Conclusions:

• The developed MgO NPs show promising cytotoxic effects on diseased cells.
• MgO NPs present a safe profile for healthy cells, suggesting potential for targeted therapies.
• The scalable synthesis method supports further investigation and development of MgO NP-based treatments.