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Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis
Yue Cao1,2, Jinyao Chen3, Qian Bian4
1Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People's Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, China.
Toxics
|November 24, 2023
Summary
Titanium dioxide nanoparticles (TiO2 NPs) can cause genotoxicity, including DNA damage and gene mutations. Factors like short-term exposure and specific cell types influence these effects.
Area of Science:
- Nanotechnology
- Toxicology
- Genetics
Background:
- Growing concerns exist regarding the genotoxic potential of titanium dioxide nanoparticles (TiO2 NPs).
- TiO2 NPs are widely utilized in various consumer and industrial products.
Purpose of the Study:
- To conduct a meta-analysis investigating the genotoxicity of TiO2 NPs.
- To identify factors that may influence TiO2 NP-induced genotoxicity.
Main Methods:
- Systematic literature search of Chinese and English studies.
- Quality assessment of included literature using established reliability and relevance methods.
- Meta-analysis and subgroup analyses performed using R software with standardized mean difference (SMD).
Main Results:
- Meta-analysis of 26 studies showed a significant association between TiO2 NP exposure and DNA damage, chromosome damage (in vivo and in vitro), and gene mutation (in vitro).
- Subgroup analysis indicated short-term exposure to TiO2 NPs exacerbates DNA damage.
- Rats and cancer cells demonstrated increased susceptibility to TiO2 NP-induced DNA damage.
Conclusions:
- TiO2 NPs possess genotoxic potential, inducing DNA damage, chromosomal aberrations, and gene mutations.
- The DNA damage response mechanism is a critical factor in TiO2 NP genotoxicity.
