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Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of
Pieter Francsois Fouche1, Christopher Stein2, Martin Nichols3
1School of Paramedicine, University of Tasmania, Rozelle, NSW, Australia.
Annals of Emergency Medicine
|November 24, 2023
Summary
Tranexamic acid (TXA) reduces death risk in trauma patients by 11% within one month. This antifibrinolytic agent shows survival benefits, especially when given early and for general trauma, without increasing clotting risks.
Area of Science:
- Emergency Medicine
- Trauma Surgery
- Pharmacology
Background:
- Hemorrhagic shock from traumatic injuries is a leading cause of preventable death.
- Tranexamic acid (TXA), an antifibrinolytic, has shown promise in reducing bleeding in trauma patients.
- Previous reviews on TXA efficacy in trauma have not incorporated the most recent clinical trial data.
Conclusions:
- The findings support the use of TXA in emergency trauma care, demonstrating a significant reduction in 1-month mortality.
- Early administration of TXA, particularly in the out-of-hospital setting and for systemic trauma, appears to confer greater survival benefits.
- The study found no compelling evidence of increased risk for vascular occlusive events with TXA use in this population.
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