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Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for
Sarah Trimpin1,2, Ellen Inutan3, Hope Coffinberger2,4
1Wayne State University, Detroit, MI, USA.
European Journal of Mass Spectrometry (Chichester, England)
|November 24, 2023
Summary
Sub-atmospheric pressure ionization mass spectrometry (MS) offers direct analysis of diverse samples. This new plate source concept enables rapid, sensitive, and robust MS applications beyond traditional laboratory settings.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
Background:
- Mass spectrometry (MS) has vast potential beyond academic labs.
- Direct ionization methods are crucial for real-world sample analysis.
Purpose of the Study:
- To present a novel plate source concept for sub-atmospheric pressure (AP) ionization MS.
- To demonstrate the capabilities of this system for direct analysis of various samples.
Main Methods:
- Utilized a plate source for direct sample introduction into the sub-AP region of an MS.
- Employed sub-AP ionization MS for analyzing volatile and nonvolatile molecules.
- Demonstrated adaptability for multiple ionization methods without venting.
Main Results:
- Achieved direct, accurate, sensitive, and straightforward analysis of small to large molecules.
- Successfully analyzed diverse and 'dirty' real-world samples.
- Showcased the robustness and speed of the sub-AP ionization MS system.
Conclusions:
- The plate source concept significantly expands the application scope of MS.
- Sub-AP ionization MS offers a practical and safe alternative to ambient ionization.
- This technology facilitates broader adoption of MS in various fields.
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