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Related Experiment Video

Updated: Jul 10, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
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Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study.

Xinxin Luo1, Zhichao Ruan2, Ling Liu3

  • 1Jiangxi Provincial People's Hospital and The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Aging Clinical and Experimental Research
|November 24, 2023
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Depression accelerates aging, shortening telomeres and increasing frailty. Conversely, a higher frailty index elevates depression risk, while muscle mass and grip strength may reduce it.

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Area of Science:

  • Genetics
  • Gerontology
  • Psychiatry

Background:

  • The relationship between depression and aging is complex and debated.
  • Understanding the causal direction is crucial for effective interventions.

Purpose of the Study:

  • To investigate the bidirectional causal relationship between depression and aging indicators.
  • To utilize Mendelian randomization to infer causality from genetic data.

Main Methods:

  • Bidirectional two-sample Mendelian randomization analysis.
  • Utilized genome-wide association study (GWAS) data for depression and age indicators.
  • Employed multiple methods (IVW, Radial MR, MRPRESSO) for robustness and sensitivity analyses.

Main Results:

  • Depression causally linked to shortened telomere length, increased frailty index, and accelerated GrimAge.
  • Frailty index causally associated with increased depression risk.
  • Appendicular lean mass and grip strength causally associated with reduced depression risk.

Conclusions:

  • Depression contributes to accelerated aging processes.
  • The frailty index is a risk factor for depression.
  • Physical health indicators like muscle mass and grip strength may be protective against depression.