The position of the left and right ventricular outlets during septation. A comparison of chicken and rat development

A comparative study was made of the relative position of the outflow tracts of chicken and rat hearts with respect to the ventricles during septation. For this purpose the position of the left and right ventricular outlet including the aortic and pulmonary valve primordia and the left and right ventricle were established with respect to the midsagittal plane of the embryo, using reconstructions of serial sections of chicken (stage 28-30) and rat (stage 28-30) embryos. In the chicken embryo no rotation of the outflow tract occurs, i.e. the position of the aortic and pulmonary valve primordia with respect to the left and right ventricle remains the same. In the rat embryo a clockwise rotation of the aortic and pulmonary valve primordia with respect to the ventricles does occur. This is in fact a detorsion. The left and right ventricle and the left ventricular outlet do not show change in position with regard to the midsagittal plane. The left ventricular outlet always straddles the interventricular septum, both lying in the midsagittal plane. These interspecies differences in the degree of detorsion of the outflow channels before septation may explain the differences in the extent of the region of contact between the endocardial outflow tract ridges.