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Visual experience induces 4-8 Hz synchrony between V1 and higher-order visual areas
Yu Tang1, Catherine Gervais1, Rylann Moffitt1
1Department of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Cell Reports
|November 24, 2023
Summary
Visual familiarity is encoded by 4-8 Hz brain oscillations in mouse visual cortex. These oscillations synchronize between primary visual cortex (V1) and higher-order visual areas (HVAs) for distinct visual feature processing and memory.
Area of Science:
- Neuroscience
- Systems Neuroscience
- Visual Processing
Background:
- Visual experience generates persistent 4-8 Hz oscillations in the primary visual cortex (V1), linked to visual familiarity.
- Higher-order visual areas (HVAs) are specialized for distinct visual features, but their role in memory processing remains unclear.
Purpose of the Study:
- To investigate whether visual memories are processed and stored within distinct visual streams.
- To examine the role of 4-8 Hz oscillations and inter-areal communication in memory-related behaviors.
Main Methods:
- Phase synchronization analysis of 4-8 Hz oscillations between V1 and HVAs (lateromedial - LM, anterolateral).
- Directed information analysis to assess functional connectivity.
- Optogenetic inactivation of LM to evaluate its role in V1 oscillations and behavior.
Main Results:
- V1 and LM, but not V1 and anterolateral, showed increased 4-8 Hz phase synchronization after stimulus entrainment.
- Directed information analysis revealed changes in top-down functional connectivity between V1 and HVAs.
- LM inactivation reduced V1 oscillation peaks and impaired visual discrimination behavior.
Conclusions:
- 4-8 Hz familiarity-evoked oscillations are specific to distinct visual features and are present in corresponding HVAs.
- These oscillations facilitate inter-areal communication between V1 and HVAs during memory-related behaviors.
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