Longitudinal changes in renal parenchymal volume and function status after partial nephrectomy: a retrospective...

Area of Science:

• Nephrology
• Urology
• Radiology

Background:

• Partial nephrectomy (PN) causes immediate ipsilateral renal parenchymal volume (RPV) decrease.
• Subsequent RPV changes and their link to rapid glomerular filtration rate (GFR) decline post-PN are not well understood.

Purpose of the Study:

• To investigate changes in ipsilateral RPV and renal function from 1-12 months to ≥1 year post-PN.
• To identify factors predicting RPV decrease and its correlation with GFR decline.

Main Methods:

• Retrospective review of 367 patients undergoing PN.
• 3D CT/MRI for RPV calculation; Spectrum score for acute kidney injury (AKI) assessment.
• GFR fast decline defined as >3 ml/min/1.73 m²/year; linear/logistic regression for predictive factors.

Main Results:

• Median ipsilateral RPV decreased significantly from 118.7 ml to 111.8 ml over a median follow-up of 21.1 months.
• Interval time and Spectrum score predicted RPV decrease rate.
• GFR fast decline (27.5% of patients) was associated with annual RPV decrease rate and overweight status.

Conclusions:

• Ipsilateral RPV shows a moderate but significant decrease post-PN, particularly with more severe AKI.
• GFR fast decline is linked to ipsilateral RPV reduction, especially in overweight individuals.