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Updated: Jul 10, 2025

Perspectives on Neuroscience

Perspectives on Neuroscience

Published on: July 31, 2007

Harnessing neuroplasticity.

Sophia Vinogradov¹

¹Department of Psychiatry and Behavioral Science, University of Minnesota Medical School, United States.

Psychiatry Research

|November 24, 2023

Summary

This summary is machine-generated.

Neuroscience-informed cognitive training improved working memory and clinical functioning in schizophrenia by enhancing brain plasticity. This approach offers a promising therapeutic avenue for cognitive deficits.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Cognitive impairments are a significant unmet need in schizophrenia treatment.
Neuroplasticity research has informed cognitive training for conditions like dyslexia.

Purpose of the Study:

To investigate if cognitive training targeting auditory cortex plasticity can improve working memory in schizophrenia.
To assess the impact of intensive cognitive training on cognitive and clinical outcomes.

Main Methods:

Experimental therapeutics studies using focused, effortful, and intensive cognitive training protocols.
Assessment of psychophysical, cognitive, serum BDNF, anticholinergic burden, electrophysiologic, brain activation, and volumetric changes.
Evaluation of 6-month clinical functioning.

Main Results:

Cognitive training led to proximal and distal cognitive improvements.
Observed increases in serum BDNF levels and positive neuroplastic changes in the brain.
Negative effects of anticholinergic burden were noted; positive responders showed better clinical functioning.

Conclusions:

Neuroscience-informed cognitive training can harness cortical plasticity for therapeutic benefit in schizophrenia.
Understanding and applying basic science of neuroplasticity is crucial for psychiatric treatments.
This approach shows potential for improving cognitive deficits and clinical outcomes in schizophrenia.