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Updated: Jul 10, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
Deep Brain Stimulation for Children with Generalized Epilepsy
Rory J Piper1, George M Ibrahim2, Martin M Tisdall1
1Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neurosurgery, Great Ormond Street Hospital, London, UK.
Abstract:
Intracranial neuromodulation is an evolving therapy for patients with drug-resistant epilepsy (DRE). Deep brain stimulation (DBS) is now available as a therapy for patients with DRE and focal-onset seizures in select health care systems; however, there remains a substantial need of efficacy data before DBS can be more widely adopted into routine clinical practice. This review and commentary focuses on a particular shifting paradigm: DBS as a therapy for children with generalized-onset seizures.
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