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Updated: Jul 10, 2025

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
Published on: December 6, 2014
New primary immunodeficiencies 2023 update
1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
New genetic testing advances rapidly identify novel inborn errors of immunity (IEI), expanding the International Union of Immunological Societies (IUIS) classification to 485 disorders. These discoveries highlight immune system complexity and homeostasis.
Area of Science:
- Immunology
- Genetics
- Medical Science
Background:
- Primary immunodeficiency diseases (PIDs), or inborn errors of immunity (IEI), are genetic disorders causing susceptibility to infections and immune dysregulation.
- The International Union of Immunological Societies (IUIS) provides a classification for these complex conditions.
Conclusions:
- The rapid identification of new IEIs underscores the specificity and complexity of the human immune system.
- These discoveries emphasize the delicate balance required for immune homeostasis.
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