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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

947
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
947
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

1.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.6K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.5K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

833
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
833
Autoimmune Disorders01:29

Autoimmune Disorders

448
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
448
Development of Immunocompetence01:22

Development of Immunocompetence

315
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
315

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Related Experiment Video

Updated: Jul 10, 2025

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
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Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

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New primary immunodeficiencies 2023 update.

Joyce E Yu1

  • 1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.

Current Opinion in Pediatrics
|November 24, 2023
PubMed
Summary
This summary is machine-generated.

New genetic testing advances rapidly identify novel inborn errors of immunity (IEI), expanding the International Union of Immunological Societies (IUIS) classification to 485 disorders. These discoveries highlight immune system complexity and homeostasis.

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Area of Science:

  • Immunology
  • Genetics
  • Medical Science

Background:

  • Primary immunodeficiency diseases (PIDs), or inborn errors of immunity (IEI), are genetic disorders causing susceptibility to infections and immune dysregulation.
  • The International Union of Immunological Societies (IUIS) provides a classification for these complex conditions.

Conclusions:

  • The rapid identification of new IEIs underscores the specificity and complexity of the human immune system.
  • These discoveries emphasize the delicate balance required for immune homeostasis.