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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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A Clinical Viewpoint on the Use of Targeted Therapy in Advanced Gastric Cancer

Magdalena Skórzewska1, Katarzyna Gęca1, Wojciech P Polkowski1

  • 1Department of Surgical Oncology, Medical University of Lublin, Radziwiłłowska 13 St., 20-080 Lublin, Poland.

Cancers
|November 25, 2023
PubMed

Insights

This review covers recent progress in advanced gastric cancer (GC) therapies, focusing on targeted treatments and immunotherapies. It highlights the shift from traditional chemotherapy to novel molecular approaches for better patient outcomes.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Advanced gastric cancer (GC) treatment is evolving beyond traditional chemotherapy.
  • New molecular targets and therapies are improving our understanding of GC.
  • Classical oncology faces challenges requiring new therapeutic strategies.

Purpose of the Study:

  • To provide a comprehensive review of clinical advancements in targeted therapy for advanced GC.
  • To explore the role of immunotherapy in advanced gastric cancer treatment.
  • To discuss the integration of novel therapeutic regimens in managing advanced GC.

Main Methods:

  • Literature review of clinical trials and studies on advanced GC therapies.
  • Analysis of recent research on molecular targets and targeted agents.
  • Evaluation of immunotherapy efficacy and application in advanced GC.

Main Results:

  • Significant progress has been made in developing targeted therapies for advanced GC.
  • Immunotherapy shows promise as a viable treatment option for advanced GC.
  • The landscape of GC treatment is shifting towards personalized molecular approaches.

Conclusions:

  • Targeted therapy and immunotherapy represent the future of advanced GC treatment.
  • Further research is needed to optimize the integration of these novel therapies.
  • Understanding molecular intricacies is key to overcoming challenges in advanced GC management.
Keywords:
gastric cancerimmunotherapytargeted therapy

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