Related Experiment Video

Updated: Jul 25, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.6K

Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Jamie Francisco1, Dominic P Del Re1

  • 1Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Antioxidants (Basel, Switzerland)
|November 25, 2023
PubMed

Insights

Acute myocardial infarction (MI) triggers inflammation during reperfusion, paradoxically worsening cardiac injury. Understanding this complex immune response is crucial for developing effective treatments to prevent heart failure progression.

Area of Science:

  • Cardiology
  • Immunology
  • Pathophysiology

Background:

  • Acute myocardial infarction (MI) involves restricted blood flow, causing cardiomyocyte loss.
  • Reperfusion therapy, while vital, initiates ischemia/reperfusion (I/R) injury, contributing to cardiac damage.
  • Inflammation, driven by immune cells, plays a key role in I/R injury, infarct expansion, and cardiac remodeling.

Purpose of the Study:

  • To investigate the intricate inflammatory response following acute myocardial infarction and ischemia/reperfusion (I/R) injury.
  • To elucidate the mechanisms regulating immune cell activation and function in the context of acute MI.
  • To identify potential therapeutic targets for mitigating I/R injury and preventing heart failure progression.

Main Methods:

  • Review of existing literature on myocardial infarction, I/R injury, and the inflammatory cascade.
  • Analysis of immune cell subsets (myeloid and lymphoid) involved in I/R pathogenesis.
  • Exploration of metabolic alterations influencing immune cell function during acute MI.

Main Results:

  • Ischemia/reperfusion (I/R) injury triggers a significant inflammatory response in the heart, involving both myeloid and lymphoid immune cells.
  • Altered metabolic status is implicated in regulating immune cell activation and function post-MI.
  • Preclinical studies show promise in targeting inflammation, but clinical translation has been limited.

Conclusions:

  • The inflammatory response post-MI and I/R is a complex process critical to cardiac injury and healing.
  • Current understanding of immune cell regulation in acute MI is incomplete, hindering therapeutic development.
  • Further research using advanced technologies is essential to characterize the inflammatory response and its impact on heart failure progression.

Keywords:
inflammationischemia/reperfusionmacrophagemyocardial infarctionneutrophil

More Related Videos

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

6.0K
Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation09:53

Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation

Published on: January 10, 2025

401

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...