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Updated: Jul 10, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis: An Update on Diagnostic Evaluation.

Sean W D Carter¹, Samantha Neubronner², Lin Lin Su^1,2

¹Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

|November 25, 2023

Summary

This summary is machine-generated.

Current diagnostic tests for chorioamnionitis lack accuracy, often detecting inflammation after fetal damage. New, minimally invasive tests are urgently needed to detect subclinical intra-uterine inflammation.

Keywords:

biomarkers chorioamnionitis diagnosis obstetric medicine sterile inflammation

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Area of Science:

Obstetrics and Gynecology
Neonatal Medicine
Reproductive Immunology

Background:

Chorioamnionitis is a significant cause of preterm birth and associated maternal and neonatal morbidity.
Intra-uterine inflammation plays a critical role in the pathophysiology of chorioamnionitis.
Existing diagnostic methods for chorioamnionitis have limitations in clinical practice.

Purpose of the Study:

To review current evidence on diagnostic tests for chorioamnionitis.
To evaluate the accuracy of existing diagnostic tests in relation to clinical practice.
To identify the need for improved diagnostic strategies for intra-uterine inflammation.

Main Methods:

Comprehensive literature search and review focusing on chorioamnionitis and intra-uterine inflammation.
Prioritization of data from randomized controlled trials and systematic reviews.
Analysis of diagnostic accuracy of clinical criteria, maternal plasma, and vaginal biomarkers.

Main Results:

Current diagnostic tests for chorioamnionitis, including clinical criteria and biomarkers, exhibit insufficient diagnostic accuracy.
Many tests detect inflammatory responses only after fetal damage has occurred.
Sterile inflammation is a key factor in chorioamnionitis, but current tests do not adequately address it.

Conclusions:

Interpretation of current chorioamnionitis diagnostic tests requires caution regarding obstetric and neonatal management.
There is an urgent need for validation of existing diagnostic tools.
Development of novel, accurate, and minimally invasive tests to detect subclinical intra-uterine inflammation is crucial.