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Updated: Jul 10, 2025

Microfluidic Chip Fabrication and Method to Detect Influenza
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Paper-Based Microfluidic Chips for Food Hazard Factor Detection: Fabrication, Modification, and Application.

Meiqi Liang1,2,3, Guozhi Zhang1,2,3, Jie Song1,2,3

  • 1Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

Foods (Basel, Switzerland)
|November 25, 2023
PubMed
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Paper-based microfluidic chips offer rapid, affordable food safety detection. This review explores their functionalization and applications in colorimetric, fluorescence, and spectroscopy analyses for enhanced food quality assessment.

Area of Science:

  • Analytical Chemistry
  • Food Science
  • Materials Science

Background:

  • Food safety and quality are critical for public health.
  • Advancements in food processing necessitate rapid, cost-effective detection methods.
  • Paper-based microfluidic chips offer a promising platform for quick analysis due to their portability and low cost.

Purpose of the Study:

  • To review the functionalization of paper-based microfluidic surfaces.
  • To provide an overview of recent research and applications in food safety detection.
  • To discuss challenges and future prospects of these analytical methods.

Main Methods:

  • Review of literature on functionalized paper-based microfluidic chips.
  • Analysis of applications in colorimetric analysis, fluorescence analysis, and surface-enhanced Raman spectroscopy.
Keywords:
detection methodfood safetymicrofluidicspaper-based device

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  • Integration of these techniques with paper-based microfluidic platforms.
  • Main Results:

    • Functionalized paper-based microfluidic chips enable swift and reliable detection of food safety issues.
    • Various analytical techniques, including spectroscopy, are effectively integrated with these platforms.
    • Demonstrated advantages include speed, cost-effectiveness, and low resource consumption.

    Conclusions:

    • Paper-based microfluidic technology is a valuable tool for rapid food safety assessment.
    • Further development is needed to overcome existing challenges and enhance future applications.
    • These platforms hold significant potential for improving global food quality monitoring.