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Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Tae-Jun Kim1, Yu Gyung Kim1, Won Jung2

  • 1Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.

Biomolecules
|November 25, 2023
PubMed

Insights

Non-coding RNAs are crucial in regulating immune responses. Their dysregulation is implicated in oral lichen planus (OLP) pathogenesis, affecting oral epithelium molecular and cellular changes.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oral Pathology

Background:

  • Oral lichen planus (OLP) is a chronic inflammatory condition affecting the oral mucosa.
  • It involves T cell infiltration and basal keratinocyte apoptosis, with multifactorial and unknown etiology.
  • Non-coding RNAs are vital for immune homeostasis and inflammatory responses, with dysregulation linked to inflammatory disorders.

Purpose of the Study:

  • To review the role of non-coding RNAs in the molecular and cellular pathogenesis of OLP.
  • To explore how non-coding RNA dysregulation contributes to OLP development.
  • To summarize current understanding of non-coding RNAs in oral epithelium changes during OLP.

Main Methods:

  • This study is a narrative review.
  • Literature search focused on non-coding RNAs and OLP pathogenesis.
  • Analysis of molecular and cellular mechanisms involved.

Main Results:

  • Non-coding RNAs are critical regulators of immunological homeostasis.
  • Dysregulation of non-coding RNAs is significantly implicated in OLP onset and progression.
  • Specific non-coding RNAs influence molecular and cellular events in the oral epithelium.

Conclusions:

  • Non-coding RNAs play a pivotal role in the pathogenesis of oral lichen planus.
  • Understanding non-coding RNA functions offers potential therapeutic targets for OLP.
  • Further research into non-coding RNA mechanisms is warranted for OLP management.
Keywords:
T lymphocytecircular RNAinflammationlong non-coding RNAmicroRNAoral lichen planus

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