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Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Martina Čižmáriková1, Radka Michalková1, Ladislav Mirossay1

  • 1Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.

Biomolecules
|November 25, 2023
PubMed

Insights

Ellagic acid (EA), a natural compound, shows promise in fighting cancer by targeting key cancer hallmarks like proliferation and inflammation. Further research into EA

Area of Science:

  • Oncology
  • Natural Product Chemistry
  • Molecular Biology

Background:

  • Cancer remains a leading cause of mortality globally, presenting significant therapeutic challenges.
  • Natural compounds are increasingly explored for their anti-cancer potential.
  • Ellagic acid (EA), a polyphenol from fruits and nuts, is a candidate for cancer prevention and treatment.

Purpose of the Study:

  • To review experimental evidence on Ellagic Acid's (EA) role in targeting cancer hallmarks.
  • To elucidate the molecular mechanisms of EA's action against cancer.

Main Methods:

  • Review of in vitro and in vivo studies on Ellagic Acid (EA).
  • Analysis of EA's impact on cancer hallmarks: proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, and genomic instability.
  • Examination of EA's modulation of signaling pathways and molecular targets.

Main Results:

  • Ellagic Acid (EA) demonstrates activity against multiple cancer hallmarks.
  • EA influences key signaling pathways and molecular targets involved in cancer progression.
  • Experimental data supports EA's potential in cancer prevention and therapy.

Conclusions:

  • Ellagic Acid (EA) exhibits multifaceted anti-cancer properties.
  • Understanding EA's mechanisms can lead to novel cancer treatment strategies.
  • EA is a promising natural compound for cancer prevention and therapy.
Keywords:
cancerchemopreventionchemotherapyellagic acidhallmarks

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