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Detecting Central Auditory Processing Disorders in Awake Mice.

Camille Dejean1,2,3, Typhaine Dupont1, Elisabeth Verpy4

  • 1Institut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France.

Brain Sciences
|November 25, 2023
PubMed
Summary
This summary is machine-generated.

Investigating central auditory processing in mice reveals that high-frequency click trains (above 60 Hz) impair neural responses, particularly in subcortical regions. This finding is crucial for understanding neurological disorders like autism.

Keywords:
auditory steady-state responseautism spectrum disordersawake micecentral auditory processing disorders

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Animal Models

Background:

  • Neurological and neurodevelopmental disorders (e.g., autism, Alzheimer's) often involve central auditory processing deficits.
  • Auditory steady-state responses (ASSRs) alterations are linked to neuronal excitation-inhibition imbalance, a common mechanism in neurological disorders.

Purpose of the Study:

  • To develop a reliable method for assessing subcortical and cortical auditory processing in awake mice.
  • To investigate central auditory processing in a Shank3 mutant mouse model of autism.

Main Methods:

  • Utilized chronically implanted electrodes in mice above the inferior colliculus and auditory cortex.
  • Presented click trains at various rates to assess auditory steady-state responses.
  • Applied the protocol to Shank3 mutant mice, a model for autism spectrum disorder.

Main Results:

  • Developed an easy, reliable, and long-lasting method for accessing complex auditory processing in mice.
  • Demonstrated impaired neural responses at high click rates (above 60 Hz) in Shank3 mutant mice.
  • Showed that this impairment is detectable subcortically, which is missed by traditional 40 Hz cortical EEG methods.

Conclusions:

  • High-frequency auditory stimulation reveals deficits in central auditory processing not detectable with standard methods.
  • This advanced technique is essential for a comprehensive investigation of auditory processing disorders in mouse models of neurological conditions.