Automatic Diagnosis of Major Depressive Disorder Using a High- and Low-Frequency Feature Fusion Framework

Major Depressive Disorder (MDD) is a common mental illness resulting in immune disorders and even thoughts of suicidal behavior. Neuroimaging techniques serve as a quantitative tool for the assessment of MDD diagnosis. In the domain of computer-aided magnetic resonance imaging diagnosis, current research predominantly focuses on isolated local or global information, often neglecting the synergistic integration of multiple data sources, thus potentially overlooking valuable details. To address this issue, we proposed a diagnostic model for MDD that integrates high-frequency and low-frequency information using data from diffusion tensor imaging (DTI), structural magnetic resonance imaging (sMRI), and functional magnetic resonance imaging (fMRI). First, we designed a meta-low-frequency encoder (MLFE) and a meta-high-frequency encoder (MHFE) to extract the low-frequency and high-frequency feature information from DTI and sMRI, respectively. Then, we utilized a multilayer perceptron (MLP) to extract features from fMRI data. Following the feature cross-fusion, we designed the ensemble learning threshold voting method to determine the ultimate diagnosis for MDD. The model achieved accuracy, precision, specificity, F1-score, MCC, and AUC values of 0.724, 0.750, 0.882, 0.600, 0.421, and 0.667, respectively. This approach provides new research ideas for the diagnosis of MDD.