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Decrease in Cerebral Blood Flow after Reoxygenation Is Associated with Neurological Syndrome Sequelae and Blood

Yanqiu Liu1,2, Fengjuan Yuan1,2, Zhongwei Peng3

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Brain Sciences
|November 25, 2023
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Summary

Returning from high altitude (HA) can alter cerebral blood flow (CBF), potentially causing neurological symptoms. This study tracked CBF changes and blood pressure in students after their return to lowlands.

Keywords:
ASLCBFHAhypoxiareoxygenation

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Area of Science:

  • Neurology
  • Physiology
  • Altitude Medicine

Background:

  • High altitude (HA) exposure alters cerebral blood flow (CBF) and cerebral circulation regulation.
  • The long-term effects of HA-induced CBF changes on neurological function and blood pressure upon return to lowlands are not well understood.

Purpose of the Study:

  • To investigate changes in CBF and cerebral artery velocity after HA exposure and subsequent reoxygenation.
  • To explore the relationship between CBF, de-acclimatization syndrome, and blood pressure in individuals returning from HA.

Main Methods:

  • Utilized magnetic resonance imaging arterial spin labeling (ASL) to measure CBF and transcranial Doppler (TCD) to assess cerebral artery velocity.
  • Monitored 23 college students at baseline, one week after returning from 4300m altitude, and three months post-return.
  • Evaluated de-acclimatization syndrome symptom scores and measured CBF and blood pressure parameters.

Main Results:

  • Cerebral artery velocity decreased one week after returning to lowlands but normalized by three months.
  • Significant regional CBF decreases were observed in areas like the putamen and thalamus, with increases in the postcentral gyrus and frontal gyrus.
  • Mean global CBF showed a decreasing trend over time and negatively correlated with systolic, pulse, and mean arterial pressure.

Conclusions:

  • Decreased CBF following reoxygenation may contribute to neurological symptoms experienced by individuals returning from high altitude.
  • Elevated blood pressure upon return from HA may predict a subsequent decrease in cerebral blood flow.