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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Updated: Jul 10, 2025

Pattern-based Search of Epigenomic Data Using GeNemo
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The Nutriepigenome.

Mario G Mirisola1

  • 1STeBiCeF Department, Università di Palermo, Building 16, Viale delle Scienze, 90128 Palermo, Italy.

Genes
|November 25, 2023
PubMed
Summary
This summary is machine-generated.

Nutrients and diet can alter the epigenome, influencing gene expression without changing DNA. This review explores how dietary strategies may counteract age-related epigenetic changes.

Keywords:
epigenetic dietfunctional dietnutrients affecting epigenomephytochemicals

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Area of Science:

  • Epigenetics and Molecular Biology
  • Nutritional Science
  • Aging Research

Background:

  • Epigenetics controls gene expression without altering DNA sequence.
  • Epigenetic modifications are dynamic and can be influenced by lifestyle factors, particularly diet.
  • The epigenome's role in modulating individual responses to nutrients is an emerging area of research.

Purpose of the Study:

  • To review the impact of nutrient consumption and diet regimens on the epigenome.
  • To explore the potential of dietary interventions in counteracting age-related epigenetic alterations.
  • To highlight the interplay between diet, epigenetics, and aging.

Main Methods:

  • Literature review of studies investigating nutrient-diet interactions and epigenetics.
  • Analysis of research on dietary components affecting epigenetic patterns.
  • Synthesis of findings on diet-driven epigenetic modifications and their implications for aging.

Main Results:

  • Nutrients and specific diet regimens demonstrably influence epigenetic patterns.
  • Dietary interventions show potential for modulating gene expression related to aging.
  • Reshaping the epigenome through diet may offer a strategy to mitigate aging effects.

Conclusions:

  • Nutrient intake and dietary choices are significant modulators of the epigenome.
  • Dietary strategies represent a promising avenue for counteracting age-associated epigenetic dysregulation.
  • Targeting the epigenome via diet could be a feasible approach to promote healthy aging.